biobakery / phylophlan

Precise phylogenetic analysis of microbial isolates and genomes from metagenomes
https://huttenhower.sph.harvard.edu/phylophlan
MIT License
128 stars 33 forks source link

The generated phylogenetic tree is missing MAGs at the leaf nodes. #119

Open ylei14 opened 1 year ago

ylei14 commented 1 year ago

Hi, Hope you're doing well. Thank you for your previous response. The previous issue has been successfully resolved, and I have obtained my phylogenetic tree. However, my leaf nodes cannot fully display my MAGs (some are missing). When I checked the log file, I found this kind of error: "Not enough markers (93/100) found in "/ifs1/User/leiyu/metagenome/Binning_dir/10GTDBtk/Phylophlan/tmp/map_aa/DG23_bin.18.b6o.bz2". After searching online and modifying my script, the problem still persists. Below is my modified script:

!/bin/bash

echo "Job Start at date"

source ~/mambaforge/bin/activate /ifs1/User/leiyu/mambaforge/envs/phylophlan

phylophlan -i /ifs1/User/leiyu/metagenome/Binning_dir/112_AA_seq -t a -d phylophlan --diversity medium -f /ifs1/User/leiyu/biosoft/phylophlan/supermatrix_aa.cfg --nproc 20 -o /ifs1/User/leiyu/metagenome/Binning_dir/10_GTDBtk/Phylophlan1/ --min_num_markers 45 --proteome_extension .pep

echo "Job End at date"

I originally thought that "--min_num_markers 45" could solve my problem, but the issue still persists, and the number of missing MAGs remains the same before and after adding "--min_num_markers 45". I used Prodigal to predict the protein sequences of the MAGs and built a phylogenetic tree based on the protein sequences. Could you please help me address the above issues?

Looking forward to your reply. cheers