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bioinfo-biols / CIRI-long

Circular RNA Identification for Nanopore Sequencing
https://ciri-cookbook.readthedocs.io
MIT License
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alternative splicing events detecting in different conditions #17

Closed JinwenBioinfo closed 2 years ago

JinwenBioinfo commented 2 years ago

Hi, is it a good strategy to detect differential alternative splicing events that I collapse the circRNAs for each sample and then compare ASs between conditions ? E.g. I have 3 cancer samples and 3 normal samples. I would collapse circRNAs individually, then compare the ASs between the cancer and normal.

Kevinzjy commented 2 years ago

It's OK, but I believe collapsing all samples together should get better results.

JinwenBioinfo commented 2 years ago

Thanks.