Thank you very much for the very useful tool you have developed.
I used the CIRI-DE module to perform differential circRNA analysis without biological replicates. The output file has a total of more than 4800 lines, but the control and treatment I input only have a total of more than 5000 circRNAs. I wonder if these are all significantly different circRNAs? Should I filter further? What should be the biological meaning and threshold of DE-score and DS-score?
Thank you very much for the very useful tool you have developed. I used the CIRI-DE module to perform differential circRNA analysis without biological replicates. The output file has a total of more than 4800 lines, but the control and treatment I input only have a total of more than 5000 circRNAs. I wonder if these are all significantly different circRNAs? Should I filter further? What should be the biological meaning and threshold of DE-score and DS-score?