biolink / biolink-model

Schema and generated objects for biolink data model and upper ontology
https://biolink.github.io/biolink-model/
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Add new clinical edge attributes to model #1301

Open karafecho opened 1 year ago

karafecho commented 1 year ago

The issue is to request the addition of three new clinical edge attributes to Biolink model. These were standardized across the clinical KPs (COHD, Multiomics EHR Risk Provider, ICEES KG) and will be exposed by the Translator Curated Query Service for use in O&O and the UI.

Here are the attributes and consensus definitions:

log_odds_ratio: The logarithm of the odds ratio, or the ratio of the odds of event Y occurring in an exposed group versus the odds of event Y occurring in a non-exposed group.

log_odds_ratio_95_ci: The ninety-five percent confidence range in which the true log odds ratio for the sample population falls.

total_sample_size: The total number of patients or participants within a sample population.

Note that the definitions were adapted from the descriptions provided in https://www.ncbi.nlm.nih.gov/books/NBK431098/, for supporting evidence.

A discussion and 'vote' can be found here: https://github.com/NCATSTranslator/Clinical-Data-Committee-Tracking-Voting/discussions/26.

Tag relevant members for discussion @sierra-moxon

CaseyTa commented 1 year ago

Could I please add on to this request to add a log odds analysis result? Something like

  log odds analysis result:
    is_a: study result
    description: >-
      A result of a log odds ratio analysis.

This request is more specific to COHD since we're the only clinical team using the study result structure.

karafecho commented 1 year ago

@sierra-moxon : I would like to reopen this ticket in order to make a minor (but important) change to the definition of log_odds_ratio. (Bolding for your purposes only.)

_log_oddsratio: The natural logarithm of the odds ratio, or the ratio of the odds of event Y occurring in an exposed group versus the odds of event Y occurring in a non-exposed group.

Thanks!

nlharris commented 1 year ago

@karafecho do you not have permission to reopen it?

karafecho commented 1 year ago

Correct. I have permission to close but not reopen issues.

nlharris commented 1 year ago

huh, weird, i wonder why those are different. anyway, i reopened it.

karafecho commented 1 year ago

Thanks!