Open vdancik opened 10 months ago
@vdancik - can we discuss this at a Chemical WG meeting
this is a metabolized chemical rather than a metabolite produce in-situ.
"An active metabolite specifically refers to a metabolite that retains pharmacological activity—that is, it has the ability to produce a therapeutic or physiological effect. Active metabolites are often of interest in pharmacology and drug development because they contribute to the overall pharmacological profile of a drug, including its efficacy and safety.
So, while all active metabolites are metabolites, not all metabolites are necessarily active in producing pharmacological effects. In Inxight Drugs, these distinctions likely help users understand the metabolic pathways of drugs and their metabolites, as well as their potential clinical significance."
Is your feature request related to a problem? Please describe. Representing active metabolites in Inxight:Drugs: https://drugs.ncats.io/drug/Q3JTX2Q7TU
What working group (or team) did this request originate from? MolePro
Describe the solution you'd like Add a new predicate
biolink:is_active_metabolite_of
/biolink:has_active_metabolite
that would be child ofbiolink:is_metabolite_of
/biolink:has_metabolite