search

biolink / biolink-model

Schema and generated objects for biolink data model and upper ontology
https://biolink.github.io/biolink-model/
Other
170 stars 71 forks source link

representing active metabolites #1414

Open vdancik opened 10 months ago

vdancik commented 10 months ago

Is your feature request related to a problem? Please describe. Representing active metabolites in Inxight:Drugs: https://drugs.ncats.io/drug/Q3JTX2Q7TU

What working group (or team) did this request originate from? MolePro

Describe the solution you'd like Add a new predicate biolink:is_active_metabolite_of / biolink:has_active_metabolite that would be child of biolink:is_metabolite_of / biolink:has_metabolite

sierra-moxon commented 5 months ago

@vdancik - can we discuss this at a Chemical WG meeting

this is a metabolized chemical rather than a metabolite produce in-situ.

sierra-moxon commented 4 months ago

"An active metabolite specifically refers to a metabolite that retains pharmacological activity—that is, it has the ability to produce a therapeutic or physiological effect. Active metabolites are often of interest in pharmacology and drug development because they contribute to the overall pharmacological profile of a drug, including its efficacy and safety.

So, while all active metabolites are metabolites, not all metabolites are necessarily active in producing pharmacological effects. In Inxight Drugs, these distinctions likely help users understand the metabolic pathways of drugs and their metabolites, as well as their potential clinical significance."