biothings / biothings_explorer

TRAPI service for BioThings Explorer
https://explorer.biothings.io
Apache License 2.0
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adding more x-bte annotation for v3 Monarch API #790

Open colleenXu opened 8 months ago

colleenXu commented 8 months ago

In https://github.com/biothings/biothings_explorer/issues/774, we migrated to the new v3 Monarch API (using the /association endpoint). This is one of the https://github.com/biothings/biothings_explorer/issues/774#issuecomment-1956088818 that may be useful to do.

  • investigate the new query options? subject/object category, taxon, namespace: example
    • look at what adds coverage, is good to have as separate operations (namespace, species context?). For example, is there cell-level/organelle-level gene-expression info?
  • annotating more MetaEdges (not covered by past operations)
click to see MetaEdges

* Chem to Pathway: unclear how helpful this is, since chemicals seem generic (water, ADP, ATP...). [Example](https://api-v3.monarchinitiative.org/v3/api/association?category=biolink:ChemicalToPathwayAssociation&object=Reactome:R-HSA-1369007&direct=true&format=json&limit=500&offset=0). 1 Predicate: `participates_in` * their prefix `Reactome` differs from what we use (REACT)...so this may require extra post-processing support (depends on how helpful setting the subject/object namespace is) * unclear if other Pathway namespaces exist * Gene to Pathway: previously chose not to annotate because MyGene also covers this info. Also has prefix issue (see Chem to Pathway above). 1 Predicate: `participates_in` * Gene to GO BiologicalProcess (989349 items): previously chose not to annotate because MyGene also covers this info. Each kind has multiple possible predicates, lots of diff primary knowledge sources * `actively_involved_in` (797927) * `acts_upstream_of_or_within` (180729) * `acts_upstream_of` (9327) * `acts_upstream_of_or_within_positive_effect` (507) * `acts_upstream_of_positive_effect` (506) * `acts_upstream_of_or_within_negative_effect` (178) * `acts_upstream_of_negative_effect` (175) * Gene to GO MolecularActivity (848151 items): see notes for BiologicalProcess above * `enables` (841330) * `contributes_to` (6821) * Gene to GO CellularComponent (745837 items): see notes for BiologicalProcess above * `located_in` (502225) * `active_in` (145515) * `part_of` (94049) * `colocalizes_with` (4048) * [Gene to Gene ortholog](https://api-v3.monarchinitiative.org/v3/api/association?category=biolink%3AGeneToGeneHomologyAssociation&subject=HGNC%3A9508&direct=false&format=json&limit=10&offset=0): previously chose not to annotate because MyGene also covers this info. 1 predicate (`orthologous_to`, 551383 hits). Seems to be 1 primary knowledge source (panther)

colleenXu commented 5 months ago

Very useful info - the csv here: https://github.com/monarch-initiative/monarch-app/issues/675#issuecomment-2138298559

Has some breakdown by namespace + category, but not taxon.