new data source: dgidb

[andrewsu]

drug-gene interaction database

downloads page: http://www.dgidb.org/downloads

[andrewsu]

snippet from the head of the current interactions file:

gene_name	gene_claim_name	entrez_id	interaction_claim_source	interaction_types	drug_claim_name	drug_claim_primary_name	drug_name	drug_concept_id	interaction_group_score	PMIDs
CDK7	CDK7	1022	CancerCommons	inhibitor	SNS-032	SNS-032	BMS-387032	chembl:CHEMBL296468	0.82
VDR	VDR	7421	DTC		NIFEKALANT	NIFEKALANT	NIFEKALANT	chembl:CHEMBL360861	0.12
GPR55	GPR55	9290	DTC		BISACODYL	BISACODYL	BISACODYL	chembl:CHEMBL942	0.75
DPYD	BE0000960	1806	DrugBank		DB03419	Uracil	URACIL	chembl:CHEMBL566	2.52	########
NR1H4	NR1H4	9971	DTC		PENTACHLOROPHENOL	PENTACHLOROPHENOL	PENTACHLOROPHENOL	chembl:CHEMBL75967	0.06
FGFR2	FGFR2	2263	JAX-CKB		AZ6089	AZ6089				22869148
APOE	APOE	348	NCI		PREDNISONE	PREDNISONE	PREDNISONE	chembl:CHEMBL635	0.18	3185288
BLM	BLM	641	DTC		9,10-PHENANTHRENEQUINONE	9,10-PHENANTHRENEQUINONE	9,10-PHENANTHRENEQUINONE	chembl:CHEMBL51931	0.02
P2RX7	P2X purinoceptor 7	5027	TTD		Pyridazinone derivative 1	Pyridazinone derivative 1
TRPC6	7225	7225	GuideToPharmacology	blocker	1.36E+08	ACAA

Currently there are:

• 100274 records in this file
• 70249 records after requiring both a gene ID and a compound ID
• 22883 records after additionally requiring a PMID as evidence.

[andrewsu]

Note also that this resource is also available through https://biothings.ncats.io/dgidb, decreasing the importance of adding it to mychem.info directly...