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MERS-CoV spillover at the camel-human interface
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Essential revision 2 #20

Closed evogytis closed 6 years ago

evogytis commented 7 years ago

p4, 'Our analyses recover these results despite sequence data heavily skewed towards non-uniformly sampled human cases and are robust to choice of prior.' This is a quite nice result and raises the question if skewed sampling would bias estimates if using a substitution model approach ('discrete trait analysis', DTA). It would strengthen the paper to include a comparison of the structured coalescent estimates to another method for ancestral states; the most popular approach in beast has been substitution models (DTA). These may give divergent results because of skewed sampling. It would be rather easy for the authors to run a DTA and if biased, this would serve as a good cautionary example when sampling is highly skewed towards one deme.

evogytis commented 7 years ago

Seems pretty simple. I'll set up a few runs with a CTMC model.

trvrb commented 6 years ago

This is nicely done. I wouldn't change a thing.