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MERS-CoV spillover at the camel-human interface
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Camel demography #6

Closed trvrb closed 7 years ago

trvrb commented 7 years ago

@evogytis ---

In terms of reviewer concerns, I'm most worried about the section on demography and Ne*tau in camels. It arrives in the text immediately after you show that camel tree is heavily impacted by recombination (while the human clusters are themselves okay). It will be such an obvious reviewer issue that that the analysis of camel demography is confounded by recombination.

I think if you're going to keep this, it really needs a robustness test to backup main result. For this, I would suggest doing a skygrid analysis splitting up the genome into 10-genomic windows to mitigate against recombination. You want to show that Ne*tau of the windowed analysis is similar in scale to Ne*tau of the full tree. There may, of course, be other ways of doing this as well.

evogytis commented 7 years ago

Fixed via a783fd49668693e836d02958949266387d282c0d