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bm2-lab / CRISOT

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How about cas12a #1

Open SZ-qing opened 6 months ago

SZ-qing commented 6 months ago

Hello, it's very interesting to use the interaction features between molecules as encoding inputs for prediction models. Can we use the features of the 256 simulated RNA-DNA hybrids that you mentioned to train a model on the Cas12a dataset for predicting off-target situations of Cas12a?

chenqc-git commented 6 months ago

The fingerprints are computed from the RNA-DNA hybrids without Cas protein. So the fringerprints can be used to develop prediction models for the other CRISPR systems, like Cas12a. You can collect off-target data for Cas12a and develop your own prediction model.