brentp / geneimpacts

prioritize effects of variant annotations from VEP, SnpEff, et al.
MIT License
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Unknown severity: explanation? #18

Open ilykos opened 4 years ago

ilykos commented 4 years ago

Your module asked me to report the following lines. Is there an explanation to why the severity for these particular consequences create issues?

Also, how does your program treat comma separated multiline CSQ?

WARNING: unknown severity for 'G|3_prime_UTR_variant|MODIFIER|PINK1|ENSG00000158828|Transcript|ENST00000321556|protein_coding|8/8||||2021|||||||1||HGNC|14581|YES' with effect 'G' Please report this on github with the effect-string above WARNING: unknown severity for 'G|downstream_gene_variant|MODIFIER|DDOST|ENSG00000244038|Transcript|ENST00000375048|protein_coding|||||||||||905|-1||HGNC|2728|YES' with effect 'G' Please report this on github with the effect-string above WARNING: unknown severity for 'G|non_coding_transcript_exon_variant|MODIFIER|PINK1|ENSG00000158828|Transcript|ENST00000400490|processed_transcript|4/4||||1020|||||||1||HGNC|14581|' with effect 'G' Please report this on github with the effect-string above WARNING: unknown severity for 'G|downstream_gene_variant|MODIFIER|DDOST|ENSG00000244038|Transcript|ENST00000415136|protein_coding|||||||||||1182|-1||HGNC|2728|' with effect 'G' Please report this on github with the effect-string above WARNING: unknown severity for 'G|non_coding_transcript_exon_variant|MODIFIER|PINK1-AS|ENSG00000117242|Transcript|ENST00000451424|retained_intron|1/3||||1322|||||||-1||HGNC|38872|YES' with effect 'G' Please report this on github with the effect-string above WARNING: unknown severity for 'G|downstream_gene_variant|MODIFIER|DDOST|ENSG00000244038|Transcript|ENST00000464364|protein_coding|||||||||||4568|-1|cds_end_NF|HGNC|2728|' with effect 'G' Please report this on github with the effect-string above WARNING: unknown severity for 'G|downstream_gene_variant|MODIFIER|DDOST|ENSG00000244038|Transcript|ENST00000475210|processed_transcript|||||||||||1762|-1||HGNC|2728|' with effect 'G' Please report this on github with the effect-string above WARNING: unknown severity for 'G|non_coding_transcript_exon_variant|MODIFIER|PINK1|ENSG00000158828|Transcript|ENST00000492302|processed_transcript|5/5||||3377|||||||1||HGNC|14581|' with effect 'G' Please report this on github with the effect-string above WARNING: unknown severity for 'G|upstream_gene_variant|MODIFIER|AL391357.1|ENSG00000257033|Transcript|ENST00000535128|pseudogene|||||||||||158|-1||Clone_based_ensembl_gene||YES' with effect 'G' Please report this on github with the effect-string above WARNING: unknown severity for 'G|downstream_gene_variant|MODIFIER|DDOST|ENSG00000244038|Transcript|ENST00000602624|protein_coding|||||||||||905|-1||HGNC|2728|' with effect 'G' Please report this on github with the effect-string above