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brentp / geneimpacts

prioritize effects of variant annotations from VEP, SnpEff, et al.
MIT License
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Bump splice_region_variant to MED #5

Closed arq5x closed 8 years ago

arq5x commented 8 years ago

In the interest of reducing false negatives.

brentp commented 8 years ago

so this would mean that a splice_region_variant would have higher impact than a synonymous variant and therefore that a non-coding change has a higher impact than a coding change. OK?

arq5x commented 8 years ago

In the context of rare disease research, yeah I think this makes sense, though one could make arguments in either direction. On January 25, 2016 at 8:37:17 AM, Brent Pedersen - Bioinformatics (notifications@github.com) wrote:

so this would mean that a splice_region_variant would have higher impact than a synonymous variant and therefore that a non-coding change has a higher impact than a coding change. OK?

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