Closed liserjrqlxue closed 4 years ago
it's just a warning. If your vcf has REF=A and ALT=C,G and the clinvar vcf has a variant for A/C and A/G then your field with Number=1 will actually have 2 values. In the annotate clinvar with ExAC example, both VCFs have been decomposed and normalized. That is the best way to be sure your annotations are consistent.
Query vcf decomposed is not simple work for me.
I used postannotation
to add AF_Adj
and AF_EAS
to ExAC itself and got a new file as annotate db.
I think this can solve this issue and annote fast.
I annote ExAC 'AN_Adj' with op 'self' and got out-of-order warning:
Does this mater for multi-allelic query now?
I checked Annotate Clinvar With ExAC. It also use 'self' for ’AN_Adj'.