brianhie / scanorama

Panoramic stitching of single cell data
http://scanorama.csail.mit.edu
MIT License
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Can we use it on several daatsets for which we're not sure about the normalization #145

Open Sophon-0 opened 1 year ago

Sophon-0 commented 1 year ago

Hello, 1) I have a few single cell datasets that have been normalized in different ways. some are log2 TPM, some are raw counts, and some are probably just log2 raw count. I don't even know myself. Can we use scanorama on these ?

2) The output of scanorama is a low dimensional embedding. Which means that the data are actually not integrated at the gene expression level. What other methods do you recommend for this type of tasks ? I would really like to have corrected datasets at expression level. Thanks !