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broadinstitute / 2020-06-01-Evidence-of-state-switching-in-single-cell-drug-response-Broad

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Proportional differences #12

Open hkhawar opened 3 years ago

hkhawar commented 3 years ago

Goal

To find out which cluster proportions are higher in response to all drug perturbations.

Proportional difference is calculated by using equal no of drug samples at each dose to the DMSO controls (68667)

For Drug samples (shuffling and random sampling is performed)

Proportional_difference_Drugs_0 04 Proportional_difference_Drugs_0 12 Proportional_difference_Drugs_0 37 Proportional_difference_Drugs_1 11 Proportional_difference_Drugs_3 33 Proportional_difference_Drugs_10 0

Proportional_difference_Drugs_controls

hkhawar commented 3 years ago

To find out proportional difference of each drug at several doses with DMSO controls

![SQ00015142_BRD-A47598013-004-16-0](https://user-images.githubusercontent.com/36200793/108294452-9757ac00-715b-11eb-9b7a-cf1d9dac88e5.png) ![SQ00015142_BRD-A48430263-003-17-2](https://user-images.githubusercontent.com/36200793/108294458-9888d900-715b-11eb-9c30-366310932564.png) ![SQ00015142_BRD-A50311610-300-10-4](https://user-images.githubusercontent.com/36200793/108294460-99216f80-715b-11eb-8b16-7d7b2dd3d8e7.png) ![SQ00015142_BRD-A50764878-003-02-8](https://user-images.githubusercontent.com/36200793/108294462-99ba0600-715b-11eb-8d1b-720ad9674647.png) ![SQ00015142_BRD-A50998626-001-02-1](https://user-images.githubusercontent.com/36200793/108294463-9a529c80-715b-11eb-8704-93bfff0e528d.png) ![SQ00015142_BRD-A61767428-001-01-9](https://user-images.githubusercontent.com/36200793/108294464-9a529c80-715b-11eb-8cf1-4516f41da0d4.png) ![SQ00015142_BRD-A61793559-001-15-6](https://user-images.githubusercontent.com/36200793/108294466-9aeb3300-715b-11eb-87de-b2df1b3668fe.png) ![SQ00015142_BRD-A62879835-001-04-2](https://user-images.githubusercontent.com/36200793/108294467-9aeb3300-715b-11eb-8cc4-144600df1232.png) ![SQ00015142_BRD-A63236097-001-01-3](https://user-images.githubusercontent.com/36200793/108294468-9b83c980-715b-11eb-99a8-62ad90212af4.png) ![SQ00015142_BRD-A63675168-001-01-6](https://user-images.githubusercontent.com/36200793/108294470-9b83c980-715b-11eb-81a5-7bb426230b41.png) ![SQ00015142_BRD-A64485570-001-11-0](https://user-images.githubusercontent.com/36200793/108294473-9b83c980-715b-11eb-9d8b-d117bf8c89be.png) ![SQ00015142_BRD-A64553394-001-04-4](https://user-images.githubusercontent.com/36200793/108294475-9c1c6000-715b-11eb-94c1-65c6ed412cb6.png) ![SQ00015142_BRD-A64977602-001-15-9](https://user-images.githubusercontent.com/36200793/108294477-9c1c6000-715b-11eb-8d01-5770ef7fac0a.png) ![SQ00015142_BRD-A65013509-003-24-4](https://user-images.githubusercontent.com/36200793/108294478-9cb4f680-715b-11eb-8e4f-1888241ba634.png) ![SQ00015142_BRD-A65280694-003-13-7](https://user-images.githubusercontent.com/36200793/108294479-9cb4f680-715b-11eb-8285-3b1fc96bce1a.png) ![SQ00015142_BRD-A66155091-001-01-8](https://user-images.githubusercontent.com/36200793/108294480-9cb4f680-715b-11eb-9282-855c87fc6187.png) ![SQ00015142_BRD-A67616246-001-07-9](https://user-images.githubusercontent.com/36200793/108294481-9d4d8d00-715b-11eb-93b4-52e023e7a12f.png) ![SQ00015142_BRD-K44771174-066-01-0](https://user-images.githubusercontent.com/36200793/108294482-9d4d8d00-715b-11eb-8fa9-84ce63e84e3b.png) ![SQ00015142_BRD-K44827188-001-06-0](https://user-images.githubusercontent.com/36200793/108294483-9d4d8d00-715b-11eb-8f15-291e50a50b9b.png) ![SQ00015142_BRD-K45542189-048-22-1](https://user-images.githubusercontent.com/36200793/108294486-9d4d8d00-715b-11eb-98fc-8f1c9b2ea4a5.png) ![SQ00015142_BRD-K46386702-001-02-1](https://user-images.githubusercontent.com/36200793/108294487-9de62380-715b-11eb-98b9-a08d67356f4c.png) ![SQ00015142_BRD-K49111258-003-29-7](https://user-images.githubusercontent.com/36200793/108294488-9de62380-715b-11eb-9dc6-dc59cdc24af7.png) ![SQ00015142_BRD-K50163129-001-01-4](https://user-images.githubusercontent.com/36200793/108294489-9e7eba00-715b-11eb-8647-6dd3892f9915.png) ![SQ00015142_BRD-K50168500-001-07-9](https://user-images.githubusercontent.com/36200793/108294490-9e7eba00-715b-11eb-96fa-528fdcb63c14.png) ![SQ00015142_BRD-K50691590-001-02-2](https://user-images.githubusercontent.com/36200793/108294492-9f175080-715b-11eb-9e0b-0ac3b778f097.png) ![SQ00015142_BRD-K50859149-001-19-5](https://user-images.githubusercontent.com/36200793/108294493-9f175080-715b-11eb-9283-cd704e13568e.png) ![SQ00015142_BRD-K50938287-036-13-8](https://user-images.githubusercontent.com/36200793/108294495-9f175080-715b-11eb-96fb-4d1728392f10.png) ![SQ00015142_BRD-K60230970-001-10-0](https://user-images.githubusercontent.com/36200793/108294496-9f175080-715b-11eb-890b-26f0aa390942.png) ![SQ00015142_BRD-K61691541-001-01-1](https://user-images.githubusercontent.com/36200793/108294497-9fafe700-715b-11eb-9094-12255456000c.png) ![SQ00015142_BRD-K61693562-300-01-7](https://user-images.githubusercontent.com/36200793/108294498-9fafe700-715b-11eb-86b3-aec1e6a60d25.png) ![SQ00015142_BRD-K61988078-001-01-2](https://user-images.githubusercontent.com/36200793/108294500-9fafe700-715b-11eb-9486-c50789620375.png) ![SQ00015142_BRD-K62363391-001-24-9](https://user-images.githubusercontent.com/36200793/108294501-a0487d80-715b-11eb-90bc-3bff0361929f.png) ![SQ00015142_BRD-K62387885-001-01-9](https://user-images.githubusercontent.com/36200793/108294502-a0487d80-715b-11eb-9a45-d13a53dbdaa6.png) ![SQ00015142_BRD-K62391742-001-03-0](https://user-images.githubusercontent.com/36200793/108294503-a0487d80-715b-11eb-9e16-2c9a53cb16c7.png) ![SQ00015142_BRD-K62398570-300-01-2](https://user-images.githubusercontent.com/36200793/108294505-a0e11400-715b-11eb-927f-42df89230faf.png) ![SQ00015142_BRD-K62737565-003-02-6](https://user-images.githubusercontent.com/36200793/108294506-a0e11400-715b-11eb-90ac-b56dd832c861.png) ![SQ00015142_BRD-K62858456-001-01-8](https://user-images.githubusercontent.com/36200793/108294507-a0e11400-715b-11eb-8b55-ceb71378e9f6.png) ![SQ00015142_BRD-K62965247-001-04-9](https://user-images.githubusercontent.com/36200793/108294508-a179aa80-715b-11eb-882e-6698e0136301.png) ![SQ00015142_BRD-K62996583-001-10-3](https://user-images.githubusercontent.com/36200793/108294509-a179aa80-715b-11eb-90fc-fdf13188f02f.png) ![SQ00015142_BRD-K63550407-001-12-7](https://user-images.githubusercontent.com/36200793/108294510-a179aa80-715b-11eb-93e7-3f022f7991cc.png) ![SQ00015142_BRD-K63630713-001-25-8](https://user-images.githubusercontent.com/36200793/108294511-a2124100-715b-11eb-83e2-21b2502dcaa2.png) ![SQ00015142_BRD-K63675182-003-23-6](https://user-images.githubusercontent.com/36200793/108294512-a2124100-715b-11eb-9beb-4534e7efb4bf.png) ![SQ00015142_BRD-K63861289-001-19-6](https://user-images.githubusercontent.com/36200793/108294513-a2124100-715b-11eb-86e4-892123693913.png) ![SQ00015142_BRD-K64504314-001-01-8](https://user-images.githubusercontent.com/36200793/108294514-a2124100-715b-11eb-8c69-6dd63448996d.png) ![SQ00015142_BRD-K64538373-001-01-4](https://user-images.githubusercontent.com/36200793/108294516-a2aad780-715b-11eb-9383-8e13f12b8ce9.png) ![SQ00015142_BRD-K64874225-001-04-7](https://user-images.githubusercontent.com/36200793/108294517-a3436e00-715b-11eb-81fc-e2ce29cba496.png) ![SQ00015142_BRD-K64931368-003-01-4](https://user-images.githubusercontent.com/36200793/108294518-a3436e00-715b-11eb-994d-b172b06065cd.png) ![SQ00015142_BRD-K65991129-001-02-9](https://user-images.githubusercontent.com/36200793/108294521-a3436e00-715b-11eb-9046-87ef42333355.png) ![SQ00015142_BRD-K65992024-001-01-5](https://user-images.githubusercontent.com/36200793/108294524-a3436e00-715b-11eb-9a45-39f7396c3504.png) 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