broadinstitute / ABC-Enhancer-Gene-Prediction

Cell type specific enhancer-gene predictions using ABC model (Fulco, Nasser et al, Nature Genetics 2019)
MIT License
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Using our own file of promoters #218

Closed Kellydc15 closed 4 months ago

Kellydc15 commented 4 months ago

Hello,

I wanted to know the recommendation on users providing their own list of promoters for analysis. We noticed that bidirectional promoters are filtered out and we would like to include a file that incorporates these. Our own list includes promoters based off of our own annotation methods from in-house data, and from Gencode v44.

Thanks

atancoder commented 4 months ago

There are implications to the ABC score when using a different list of promoters. Read more here: https://abc-enhancer-gene-prediction.readthedocs.io/en/latest/usage/methods.html#defining-and-adding-gene-promoters