broadinstitute / ABC-Enhancer-Gene-Prediction

Cell type specific enhancer-gene predictions using ABC model (Fulco, Nasser et al, Nature Genetics 2019)
MIT License
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qnrom in config.yaml for different cells #231

Open JasonLinjc opened 3 months ago

JasonLinjc commented 3 months ago

Dear Team,

I wanted to express my deepest appreciation for creating such remarkable tools for predicting promoter-enhancer interactions. They have proven to be tremendously helpful!

I have a quick question about the use of the pipeline for different cell lines. Should I modify the "qnorm" parameter in the config.yaml file, specifically changing it from "reference/EnhancersQNormRef.K562.txt", when running the pipeline for other cell lines?

Thank you for your assistance!

Best, Jiecong

engreitz commented 3 months ago

Hi Jiecong, No, you should not modify the qnorm parameter. Use the provided file Best, Jesse

On Sat, Aug 3, 2024 at 10:19 AM Jiecong Lin @.***> wrote:

Dear Team,

I wanted to express my deepest appreciation for creating such remarkable tools for predicting promoter-enhancer interactions. They have proven to be tremendously helpful!

I have a quick question about the use of the pipeline for different cell lines. Should I modify the "qnorm" parameter in the config.yaml file, specifically changing it from "reference/EnhancersQNormRef.K562.txt", when running the pipeline for other cell lines?

Thank you for your assistance!

Best, Jiecong

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