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broadinstitute / cell-health

Predicting Cell Health with Morphological Profiles
MIT License
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Select Interesting Compounds to Validate #98

Open gwaybio opened 4 years ago

gwaybio commented 4 years ago

We will use the Repurposing Hub dashboard to select specific compounds to validate in the lab.

We will select two kinds of compounds:

  1. Compounds that are predicted to have well characterized effects (Positive Controls)
  2. Compounds that are predicted to have unexpected effects that could help to define MOA

We will use this issue to document the molecular validation approach (which can then later be transferred to a methods section)

gwaybio commented 4 years ago

Dashboard Link: https://gregway.shinyapps.io/repurposing_cellhealth_shiny/

AnneCarpenter commented 4 years ago

@niranjchandrasekaran has been working on identifying drugs (or almost-drugs) that have an unknown MOA so it might be useful to cross check against that list. Figuring out the mechanism of something currently poorly characterized would be a great outcome: https://github.com/broadinstitute/jump-cellpainting/issues/18 (private to Broad/JUMP project)