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broadinstitute / chem-bio-dos-del

Initiated 2021Q4 for code related to the Broad Chemical Biology DNA-encoded library (DEL) analysis and visualization pipeline
MIT License
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Jitter plot function cannot display selectivity #2

Open codewarrior2000 opened 2 years ago

codewarrior2000 commented 2 years ago

Shuang Liu suggested an enhancement to the DEL analysis app: "Bruce/Connor used to be able to generate jitter plots with y-axis as the enrichment, x-axis as different protein targets, and selectivity of protein of interest vs the other protein targets in the selected screen is color coded. I have pasted an example for MegaScreen 2 below. Do you think this selectivity function could be added into the app as the current jitter plot function cannot display selectivity? It would be very useful for our latest multi-BRD CiP-DEL where we are trying to find selective BRD degraders" image (3) .

codewarrior2000 commented 2 years ago

Zach S. said that the DEL analysis app does have that capability. He will be glad to discuss it with Shuang.

lius-broad commented 1 year ago

Zach S. said that the DEL analysis app does have that capability. He will be glad to discuss it with Shuang.

I think the Shiny app only allows selectivity against one protein target but not a panel of protein targets; still require action.