broadinstitute / genetic-prevalence-estimator

https://genie.broadinstitute.org/
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Add option for removing homozygotes from carrier freq and genetic prevalence estimates #213

Closed sambaxter closed 6 months ago

sambaxter commented 9 months ago

We should add an option for estimates that removed homozygotes. This would involve adding "remove homozygotes" as one of the options under the genetic prevalence estimates, it would also change the counts for the carrier frequency in the table above as well. For any variant in the list that have homozygotes this version of the formula would subtract the homozygotes from the AC (AC-2 x # of homs) before performing the calculations.