broadinstitute / grit-benchmark

Benchmarking a metric used to evaluate a perturbation strength
BSD 3-Clause "New" or "Revised" License
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Checking if plate normalization impacts grit #11

Closed gwaybio closed 3 years ago

gwaybio commented 3 years ago

It does! Whole plate normalization tends to inflate grit, especially at the highest values. However, the correlations between grit are extremely high, indicating that grit calculations are robust to normalization strategies.

cell_health_grit_platenormalization_comparison