The subclonal fraction (fraction of tumor-derived DNA that is subclonal) is 0.446 but tumor fraction is 0

broadinstitute / ichorCNA

Estimating tumor fraction in cell-free DNA from ultra-low-pass whole genome sequencing.

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The subclonal fraction (fraction of tumor-derived DNA that is subclonal) is 0.446 but tumor fraction is 0 #121

Open paulhtyang opened 1 year ago

paulhtyang commented 1 year ago

Hello,

I was trying to optimize the parameters of running ichorCNA so I got a genome-wide CNA plot showing "the subclonal fraction (fraction of tumor-derived DNA that is subclonal) is 0.446 although tumor fraction is 0". Please take a look at the figure below. I am wondering if I over-optimize the running. Thanks CT4-SynSarc1.params.txt