broadinstitute / ichorCNA

Estimating tumor fraction in cell-free DNA from ultra-low-pass whole genome sequencing.
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Samples with 0% Tumor, but chromosome deletions? #122

Open Timster28 opened 1 year ago

Timster28 commented 1 year ago

Hello,

I am using ichorCNA and we have some samples that indicate there is 0% tumor in the sample; however, there is a chromsome deletion in some of them. I can attach them all here if you would like to look at it. The GC-Map corrections are good and the mean coverage is higher than 0.1X. Some of these deletions look very small compared to the entire chromosome, but I'm having a hard time determining if these deletions are significant or not, can someone help?

Thanks, Tim UM031C2D25.seg.txt UM031EndC4.seg.txt NWC032C2D15.seg.txt