Adding Figure 1 and associated code

[gwaybio]

Figure 1. Cell Painting and L1000 data provide complimentary measurements of compound perturbations across doses. (a) Percent replicating scores calculated via median pairwise correlations between replicates of compound perturbations across dose. We generated the non-replicate distribution from matched randomly sampled non-replicate groups. See methods for full details about sampling and data processing. The dotted blue line indicates the 95th percentile of the non-replicate distribution. (b) The L1000 and Cell Painting assays reproducibly measure a complementary set of compound perturbations. The three numbers represent (from top to bottom) the number of reproducible compounds unique to L1000, the number of overlapping reproducible compounds between the two assays, and the number of reproducible compounds unique to Cell Painting. (c) Percent matching scores calculated via median pairwise correlation of level 5 consensus signatures of compounds mapping to the same mechanism of action (MOA) across dose. The dotted blue line indicates compounds significantly matched to their MOA based on a non-parametric p value (see methods). (d) The L1000 and Cell Painting assays each capture a complementary set of compound MOAs. The three numbers represent counts reflecting the ordering as described in panel b. (e) Consensus signatures of select MOAs demonstrate high heterogeneity across assays and doses.

cc @shntnu @AdeboyeML @AnneCarpenter - we'll discuss this more at check-in, but I wanted to provide you a chance to provide feedback and suggested edits. Everything here can be changed mostly easily, so feedback is welcomed!

p.s. - The remaining figures should be quicker to generate than this one

[gwaybio]

let's move discussion to #20 so I can merge this in and work on the next figure