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broadinstitute / lincs-profiling-complementarity

Analyzing and comparing signal found in different profiling technologies
BSD 3-Clause "New" or "Revised" License
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Remove bortezomib from analysis #50

Open gwaybio opened 2 years ago

gwaybio commented 2 years ago

@tnat1031 suggested to remove bortezomib from at least the clustering analysis, since it was only included as a control to assess cell death. We may or may not pursue this additional analysis, but we can include some thoughts in this issue when/if the time comes.

gwaybio commented 2 years ago

We may want to remove it from all analyses: "but thinking more about it, bortezomib is an "outlier" compound in that it's so potent and was profiled at many replicates and high dose, so it's different from the other test compounds in a variety of ways"

tnat1031 commented 2 years ago

We should remove MG-132 as well. It's a proteasome inhibitor and was included only as a cell killing control.