A reviewer asked for us to describe which MOAs fail to capture. I add this visualization to a previously "optional" supplementary figure introduced in #62
Supplementary Figure XXX. Cell Painting and L1000 differentially measure compound perturbations by mechanism of action (MOA). (a) All 40 MOAs that are consistently measured by Cell Painting, L1000, or both in at least two doses. Brackets indicate the number of times the MOA was reproducible (per dose and assay). For example, PLK inhibitors were reproducible in every dose and in each assay (6 doses x 2 assays). See Figure 2. (b) MOA median pairwise correlation and MOA average precision indicate similar high-performing MOAs. (c) The majority of MOAs are not reproducible in either assay, decreasing with increasing dose. (d) 57 MOAs (out of 112) are not reproducible in any dose or assay. Select MOAs (with less than 0 scores in either Cell Painting or L1000 assays are shown).
A reviewer asked for us to describe which MOAs fail to capture. I add this visualization to a previously "optional" supplementary figure introduced in #62