broadinstitute / lincs-profiling-complementarity

Analyzing and comparing signal found in different profiling technologies
BSD 3-Clause "New" or "Revised" License
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[Response to Review] Equal weighting ensemble #72

Closed gwaybio closed 2 years ago

gwaybio commented 2 years ago

Previously, we weighted our ensemble model by individual model test set performance. As a reviewer correctly pointed out, this implies data leakage.

Here, I update from test-set weighting to equal weighting. Our goal in the ensemble analysis was to combat any MOA-specific biases in any particular model, and equal weighting largely mitigates this bias.