Normalize Single Cells by Site

[gwaybio]

For example reduced representation experiments (230 genes; 2-4 wells) (~150,000 cells) we are able to normalize single cells in a single file using standard approaches. Two important notes:

• this approach will not adjust for technical artifacts induced by site and well
• this approach will not scale particularly easily to the millions of cells in whole genome experiments

We need to find a solution to normalize single cells within each site. This will also likely help us a bunch in our gene- and guide-level aggregated perturbation profiles.

[gwaybio]

It is likely that the single cell normalization step should happen before aggregation (and not during normalization as #16 might suggest)