broadinstitute / regional_missense_constraint

Code to calculate regional missense constraint
BSD 3-Clause "New" or "Revised" License
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Update missense badness for training/validation/testing #285

Closed lw453 closed 1 year ago

lw453 commented 1 year ago

This PR adds changes to allow the missense badness models to be generated with variant data in the following sets of transcripts: all training transcripts, all test transcripts, or k-folds of the training transcript set. These transcript sets were defined in the notebook: gs://regional_missense_constraint/notebooks/train_test_split_transcripts.ipynb

Major changes:

Minor changes:

Analogous changes to MPC-related code will be forthcoming in another PR.