broadinstitute / regional_missense_constraint

Code to calculate regional missense constraint
BSD 3-Clause "New" or "Revised" License
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Runtime fixes for v4 #309

Closed ch-kr closed 4 days ago

ch-kr commented 1 month ago

PR contains changes needed to get RMC search pipeline to run on v4/GRCh38.

Major changes:

Minor changes:

ch-kr commented 1 month ago

adding a comment that I used freeze 1 for preliminary results; we can either plan to keep this data freeze (which means we'd have to update FREEZES and CURRENT_FREEZE in rmc.py) or we can overwrite the results from this freeze when we are ready to rerun

ch-kr commented 1 month ago

also just updated call to annotate_exploded_vep_for_constraint_groupings in constraint.py to include coverage_expr arg due to PR that just got merged in gnomad_methods -- function now has/expects this arg