broadinstitute / regional_missense_constraint

Code to calculate regional missense constraint
BSD 3-Clause "New" or "Revised" License
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Basic question of using the MPC pipeline #311

Open ryshi06 opened 1 month ago

ryshi06 commented 1 month ago

Hello, Thanks for the talented idea of generating such a convenient score for variant prediction. I am quite new for using Python. I have a quick question on applying the MPC pipeline to my annotated data. At the current stage, I have an annotated vcf file with information added from several sources including gnomAD, ClinVar, REVEL and CADD. I am wondering is this vcf file appropriate to use as the MPC pipeline input?

Thanks, Ruyu