Including high SpliceAI score as a type of always returned (like ClinVar variants)

[anneodonnell]

Letting high SpliceAI scores (maybe check boxes for red and yellow range) where variants with high spliceAI scores will be returned like ClinVar variants get returned (following same rules as ClinVar).

[hanars]

We also have this open ticket about filtering by cadd: https://github.com/macarthur-lab/seqr/issues/361

I'll probably want to implement all the in silico filtering in one coherent update. Could you fill in some details here about exactly which in silico predictors we want to be able to filter by, and how we want overriding to work?

[bw2]

Personally, I found it intuitive to have a single Annotations section like

I think that way it's clearer that selecting more checkboxes leads to more search results, and these SpliceAI and other filters would fit there.

[hanars]

I would want to lay these out a bit differently, but I'm not totally opposed to having them in one big section. That said, I would really want actual analyst feedbac before making that decision. I personally find it really confusing to display things as though being clinvar pathogenic is in any way the same as being a frameshift variant is anything the same as having a high splice AI

[bw2]

they are technically all annotations and the unifying section logic is "show any variant that has/is at least one of these".

[hanars]

Like I said, you and I feel differently and the opinion I care about is the analysts'

[hanars]

Duplicated by https://github.com/broadinstitute/seqr/issues/2186