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broadinstitute / seqr

web-based analysis tool for rare disease genomics
GNU Affero General Public License v3.0
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PanelApp Gene List - 413 error #2848

Closed lynnpais closed 2 years ago

lynnpais commented 2 years ago

Describe the bug Variant search using the MOI filter for PanelApp is leading to a search error

Link to page(s) where bug is occurring https://seqr.broadinstitute.org/variant_search/results/a39ab90b34c7ed4b3dbb07a10b90d8af?page=1&sort=xpos

Scope of the bug NA

Screenshots

Screen Shot 2022-07-19 at 4 36 03 PM
hanars commented 2 years ago

please provide a screenshot or description of the full search params you did

lynnpais commented 2 years ago

Using another example here, which is giving the same error - for SHE_1363, I ran a standard de novo/dominant permissive search, selected the Mendeliome PanelApp gene list and set MOI to Dominant.

Screen Shot 2022-07-20 at 12 31 58 PM Screen Shot 2022-07-20 at 12 32 06 PM
hanars commented 2 years ago

FYI @david-ma - PR: https://github.com/broadinstitute/seqr/pull/2851

hanars commented 2 years ago

this is now working: https://seqr.broadinstitute.org/variant_search/results/b6075ad0e2c92808b53c04eacea297bd?page=1&sort=xpos

david-ma commented 2 years ago

I was unable to reproduce this bug or #2847 locally but I have cherry picked the new fixes for mcri, thanks Hana!

hanars commented 2 years ago

to recreate you need to select a very large gene list. It is also possible that your ngnx/ server configuration has a different max request size threshhold than ours

hanars commented 2 years ago

also there was a small bug in this, the fix is here: https://github.com/broadinstitute/seqr/pull/2859