Does the RNAmatrix need to be scaled?

buenrostrolab / FigR

Functional Inference of Gene Regulation

https://buenrostrolab.github.io/FigR/

MIT License

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Does the RNAmatrix need to be scaled? #23

Open sylestiel opened 1 year ago

sylestiel commented 1 year ago

Hi @vkartha,

Can you comment on the choice of scaling the RNA data? Does this affect the outcome?
Please clarify.

Also if I am calling in a subset from a larger dataset analysed using Signacwould you recommend repeating dimensionality reduction and repeat of nearest neighbour paramenters before running figR?