bneale
commented
8 years ago Hi
Yes - with only 300 samples you're extremely underpowered for this kind of analysis as you need sufficient sample size to start to expose the polygenic effects on the trait in question.
Best Ben
On Friday, October 23, 2015, argossy notifications@github.com wrote:
Hi my h2 estimate is negative (shown below). I didn't have any issue during data munging. So I don't know what's wrong. BTW, my sample size is 300+, do you think is it too small for estimating heritability or genetic correlation? Thank you
Total Observed scale h2: -1.105 (1.5709) Lambda GC: 1.0436 Mean Chi^2: 1.0409 Intercept: 1.0478 (0.0093) Ratio: 1.1669 (0.2275)
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Benjamin Neale, Ph.D. Assistant Professor Analytic and Translational Genetics Unit Massachusetts General Hospital Institute Member Stanley Center for Psychiatric Disease and Program in Medical and Population Genetics Broad Institute
Hi my h2 estimate is negative (shown below). I didn't have any issue during data munging. So I don't know what's wrong. BTW, my sample size is 300+, do you think is it too small for estimating heritability or genetic correlation? Thank you
Total Observed scale h2: -1.105 (1.5709) Lambda GC: 1.0436 Mean Chi^2: 1.0409 Intercept: 1.0478 (0.0093) Ratio: 1.1669 (0.2275)