search

bulik / ldsc

LD Score Regression (LDSC)
GNU General Public License v3.0
652 stars 345 forks source link

rg with sample overlap #419

Open Cui4399 opened 8 months ago

Cui4399 commented 8 months ago

I want to run rg with two GWAS summary statistics, both derived from Finngen. Should I make some additional restrictions to correct sample overlap?

aksarkar commented 6 months ago

@Cui4399 The intercept term of genetic correlation absorbs residual confounding, sample overlap, and phenotypic correlation. You do not need to perform additional steps to fit the model.