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bulik / ldsc

LD Score Regression (LDSC)
GNU General Public License v3.0
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rg with sample overlap #419

Open Cui4399 opened 6 months ago

Cui4399 commented 6 months ago

I want to run rg with two GWAS summary statistics, both derived from Finngen. Should I make some additional restrictions to correct sample overlap?

aksarkar commented 4 months ago

@Cui4399 The intercept term of genetic correlation absorbs residual confounding, sample overlap, and phenotypic correlation. You do not need to perform additional steps to fit the model.