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bvieth / powsimR

Power analysis is essential to optimize the design of RNA-seq experiments and to assess and compare the power to detect differentially expressed genes. PowsimR is a flexible tool to simulate and evaluate differential expression from bulk and especially single-cell RNA-seq data making it suitable for a priori and posterior power analyses.
https://bvieth.github.io/powsimR/
Artistic License 2.0
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pLFC input question #52

Closed jstansfield0 closed 3 years ago

jstansfield0 commented 3 years ago

I'm confused by the wording in the help for the pLFC option in the Setup() function. If I want to check power for a constant fold change of 2, how should I be entering the pLFC option? As pLFC = log2(2) or pLFC = 2?

bvieth commented 3 years ago

Hello, the input pLFC should be on log-scale, so already log-transformed. Thus pLFC should be equal to 2.