Background: We want a rare variant analysis module because much of the variance in rare disease incidence is explained by rare mutations. We want to create rare variant methods and use those in publications to push the field of genetics forward.
Task List:
[x] #249
[x] #250
[x] Convert Dave's simulation to python and match in terms of summary counts
[ ] Write out correct statistical model for genetic correlation with Dave's agreement
To generate data and what we should be modeling
[ ] #251
[x] #315
[ ] Identify best performing model to use as base for multivariate version and communicate results to Dave
[ ] Test the same models on our N>3 condition simulation and write down results
[x] Add Bystro Scientific Repo for experimental models that we want to publish on
Background: We want a rare variant analysis module because much of the variance in rare disease incidence is explained by rare mutations. We want to create rare variant methods and use those in publications to push the field of genetics forward.
Task List:
[x] #249
[x] #250
[x] Convert Dave's simulation to python and match in terms of summary counts
[ ] Write out correct statistical model for genetic correlation with Dave's agreement
To generate data and what we should be modeling
[ ] #251
[x] #315
[ ] Identify best performing model to use as base for multivariate version and communicate results to Dave
[ ] Test the same models on our N>3 condition simulation and write down results
[x] Add Bystro Scientific Repo for experimental models that we want to publish on
[x] #253
[x] #254