caleblareau / mgatk

mgatk: mitochondrial genome analysis toolkit
http://caleblareau.github.io/mgatk
MIT License
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Apply mgatk to scRNA-seq data #78

Closed FionaMoon closed 1 year ago

FionaMoon commented 1 year ago

Hi all, I wonder if I can apply mgatk to scRNA-seq data (such as SMART-Seq2, 10x)? I've read the article which applies mgatk to scATAC-seq and the performance of mgatk is pretty good.

I used to do variants calling of scRNA-seq data by first split cell barcodes of bam and then go gatk pipeline. This pipeline is complicated and inaccurate. So, I'd like to try other pipelines(like mgatk) designed for single-cell technology.

Thank you in advance!