califano-lab / PISCES

R package for Protein activity analysis of single-cell RNAseq.
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Usage with integrated data? #1

Open hummuscience opened 4 years ago

hummuscience commented 4 years ago

Hello! I am excited to see your package and to try it out :)

Since the integration of multiple datasets has become more popular lately I was wondering what the best approach would be to use your package with such data.

To my knowledge, no package produces "corrected" counts after integration, and using the original normalized counts matrix is troublesome. Many packages use the PCA (or integration) embedding for downstream analysis. Is it possible to do the same here?

Thank you for your input!