Student 1 Verification: Peanut Allergy (drugs)

[callahantiff]

Student (GitHub Username): @deringtonc Verification Number: 1

Verification Assignments: Peanut Allergy

• Phenotype Definition
• Spreadsheet

[deringtonc]

@callahantiff @trinklek This row is the row you need to use as the PRIME example for why this work is necessary!!!

https://docs.google.com/spreadsheets/d/1Va7cin600gumAUxQ-MT6InADK87iIwpqR0Qmca22dCc/edit#gid=1496971796&range=9:9

[deringtonc]

@callahantiff Just to clarify for documentation purposes, products in this spreadsheet are those that are used to diagnose peanut allergy, NOT for treatment of peanut allergy.

[callahantiff]

@callahantiff Just to clarify for documentation purposes, products in this spreadsheet are those that are used to diagnose peanut allergy, NOT for treatment of peanut allergy.

@deringtonc - this is the phenotype with the least amount of direction. The only information they give us is:

Which is why you are seeing so many weird things! :D But, to answer your question, yes, these codes are primarily being used to identify patients that are likely to have a peanut allergy.

[callahantiff]

@callahantiff @trinklek This row is the row you need to use as the PRIME example for why this work is necessary!!!

https://docs.google.com/spreadsheets/d/1Va7cin600gumAUxQ-MT6InADK87iIwpqR0Qmca22dCc/edit#gid=1496971796&range=9:9

@deringtonc - absolutely, what a hilarious example!

[trinklek]

@callahantiff @trinklek This row is the row you need to use as the PRIME example for why this work is necessary!!! https://docs.google.com/spreadsheets/d/1Va7cin600gumAUxQ-MT6InADK87iIwpqR0Qmca22dCc/edit#gid=1496971796&range=9:9

@deringtonc - absolutely, what a hilarious example!

Nice! It is an example that resonates with anyone, irrespective of whether they are clinical or not.

[trinklek]

@callahantiff Just to clarify for documentation purposes, products in this spreadsheet are those that are used to diagnose peanut allergy, NOT for treatment of peanut allergy.

@deringtonc - this is the phenotype with the least amount of direction. The only information they give us is:

Which is why you are seeing so many weird things! :D But, to answer your question, yes, these codes are primarily being used to identify patients that are likely to have a peanut allergy.

@deringtonc @callahantiff KD, if the goal is to identify patients with peanut allergy, wouldn't we want to capture things that establish a diagnosis AND those things that treat peanut allergy? If you are using something to treat peanut allergy, doesn't that suggest they have peanut allergy?

[deringtonc]

@trinklek definitely agree! But, none of the drugs that would treat an allergy (like: epinephrine injection or Benadryl) are in this sheet...

[trinklek]

@trinklek definitely agree! But, none of the drugs that would treat an allergy (like: epinephrine injection or Benadryl) are in this sheet...

@deringtonc Got it! Perhaps because they are too non-specific. Irrespective, that surprises me that they are not included, given paroxetine was included for ADHD (more non-specific and grasping for straws).

[deringtonc]

@trinklek definitely agree! But, none of the drugs that would treat an allergy (like: epinephrine injection or Benadryl) are in this sheet...

@deringtonc Got it! Perhaps because they are too non-specific. Irrespective, that surprises me that they are not included, given paroxetine was included for ADHD (more non-specific and grasping for straws).

@trinklek I agree.

@callahantiff is it possible to revise the phenotype to include prescriptions for epinephrine injections ("Epi-Pens")? I think this might help. Right now we only have peanut allergy skin tests - some people had the skin tests done elsewhere/outside the health system or know they have an allergy from prior exposure. So having an Epi-Pen prescription + any mention of "peanut" in other types of strings might be more indicative of peanut allergy

[callahantiff]

@trinklek definitely agree! But, none of the drugs that would treat an allergy (like: epinephrine injection or Benadryl) are in this sheet...

@deringtonc Got it! Perhaps because they are too non-specific. Irrespective, that surprises me that they are not included, given paroxetine was included for ADHD (more non-specific and grasping for straws).

@trinklek I agree.

@callahantiff is it possible to revise the phenotype to include prescriptions for epinephrine injections ("Epi-Pens")? I think this might help. Right now we only have peanut allergy skin tests - some people had the skin tests done elsewhere/outside the health system or know they have an allergy from prior exposure. So having an Epi-Pen prescription + any mention of "peanut" in other types of strings might be more indicative of peanut allergy

@deringtonc - I love this idea. In general, there will be two approaches we take when trying to replicate these phenotypes. The first way is to try and replicate the approach the phenotype authors defined and the second is to expand the phenotype author's definition to include additional "expert knowledge" like what you mentioned above. So, we will definitely come back to this!

[deringtonc]

Completed peanut allergy drug string review on 6/10.

Opened a new issue #93 to reconsider the phenotype definition.