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cancerit / telomerecat

Telomerecat: The telomere computational analysis tool
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Telomere length not as expected in healthy blood #47

Open Urja25 opened 8 months ago

Urja25 commented 8 months ago

Hi,

I am using Telomerecat to estimate telomere length in two different healthy donor blood samples. I have high coverage WGS data for both samples.

On running Telomerecat, I get the following telomere lengths: D27H: 3132.9 bp (too short) D28H: 26131.3 bp (expected range) I ran telomerecat separately on these samples.

When I ran the samples as a batch, i got the following lengths: D27H: 3139.9 bp D28H: 5708.7

Then I tried to run D27H again, i got the following length: D27H: 3132.9 bp

Can you please explain the discrepancies I am seeing and why the telomere length is short for D27H? D27H is 21Y and therefore age cannot explain this.