Add Kolmogorov–Smirnov test to calculateNearestNeighborProbabilities

ccb-hms / scDiagnostics

Diagnostic functions to assess the quality of cell type annotations in single-cell RNA-seq data

https://ccb-hms.github.io/scDiagnostics/

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Closed AnthonyChristidis closed 3 months ago

AnthonyChristidis commented 4 months ago

We can approximate the distribution of the nearest neighbor probability under the null hypothesis that the two datasets are perfectly aligned (via Binomial-Normal approximation).
Then we can apply the nonparametric Kolmogorov–Smirnov test to test the null hypothesis.

AnthonyChristidis commented 3 months ago

Added Binomial-Normal approximation, but the K-S test would not be needed.