ccmbioinfo / crg2

Research pipeline for exploring clinically relevant genomic variants
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SV reports: add in read depth and alt allele depth (and maybe genotype) #191

Open Madelinehazel opened 10 months ago

Madelinehazel commented 10 months ago

Our BND reports have columns denoting depth, as well as the reads supporting the alternate allele and reference allele, but our SV reports do not. In order to add this information, you will have to pull it from the metaSV VCF:

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You will have to pull this information for each sample and integrate that code in the SVGrouper code. This script pulls in the metaSV VCF for each family member and extracts the variants, grouping them by reciprocal overlap. This will result in three new columns for each sample, e.g:

family_sample1_REF_DEPTH, family_sample1_ALT_DEPTH, family_sample1_DEPTH family_sample2_REF_DEPTH, family_sample2_ALT_DEPTH, family_sample2_DEPTH family_sample3_REF_DEPTH, family_sample3_ALT_DEPTH, family_sample3_DEPTH