Ensure model consistency in MCMC

[fumer100]

Do I ensure model consistency in MCMC the same way I did in the trajectory? Should I undo a mutation even if it fixates ?

[charlesrocabert]

Yes, if the mutation leads to an inconsistent model, you must reject it

[fumer100]

My growth-rates with MCMC for EC12b are very small in comparison to the other trajectories. Is that normal? With noisy trajectory : With MCMC :

[charlesrocabert]

Yes it might make sense. As I explained to you, with MCMC, you can get stuck in a flat region of the fitness landscape. But you should plot the trajectory to have a better idea

[fumer100]

I thought of implementing the following plots:

• Fluxfraction to time: (maybe find EFMs and just display the 'important' fluxfractions)
• Growthrate to mutation events:
• growthrate to time
• Selecetion coefficient to number of mutation events

Do you have any other ideas or suggestions on what could be useful to see?