Open fumer100 opened 1 month ago
Yes, if the mutation leads to an inconsistent model, you must reject it
My growth-rates with MCMC for EC12b are very small in comparison to the other trajectories. Is that normal? With noisy trajectory : With MCMC :
Yes it might make sense. As I explained to you, with MCMC, you can get stuck in a flat region of the fitness landscape. But you should plot the trajectory to have a better idea
I thought of implementing the following plots:
Do you have any other ideas or suggestions on what could be useful to see?
Do I ensure model consistency in MCMC the same way I did in the trajectory? Should I undo a mutation even if it fixates ?