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chhylp123 / hifiasm

Hifiasm: a haplotype-resolved assembler for accurate Hifi reads
MIT License
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continuous on the unitig graph but breaked after Hi-C resolving #219

Open zhangrengang opened 2 years ago

zhangrengang commented 2 years ago

The below is an example: the two chromosome-level haplotypes are continuous on the unitig graph, but in the final hic.p_ctg, one unitig (charactered as “A”) is breaked. hifiasm The black lines indicate correspondences between unitigs and HiC-resolved contigs.

chhylp123 commented 2 years ago

Do you mean it is a misassembly or unexpected breakpoints?

zhangrengang commented 2 years ago

It should be an unexpected breakpoint, as it is connected on the unitig graph and neighboured on the Hi-C heatmap.

zhangrengang commented 2 years ago

The breakpoint is absent with another HiC dataset by a different enzyme.