For trio-binning assemblies, is it OK to use Hi-C reads from mother and father to construct K-mer to be fed into the program? This is because some Hi-C libraries such as Dovetail Omni-C have almost shot-gun sequencing style coverage along the genome, and I think treating these Hi-C reads as single-ended reads will give a similar k-mer results to reads from a direct short-gun library?
Thanks, I really appreciate any input on that!
Tianzhu
Hi!
For trio-binning assemblies, is it OK to use Hi-C reads from mother and father to construct K-mer to be fed into the program? This is because some Hi-C libraries such as Dovetail Omni-C have almost shot-gun sequencing style coverage along the genome, and I think treating these Hi-C reads as single-ended reads will give a similar k-mer results to reads from a direct short-gun library?
Thanks, I really appreciate any input on that! Tianzhu