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choderalab / bayesian-itc

Python tools for the analysis and modeling of isothermal titration calorimetry (ITC) experiments.
GNU General Public License v3.0
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Naproxen experiments #5

Closed bas-rustenburg closed 9 years ago

bas-rustenburg commented 9 years ago

Sodium concentration seems to affect the affinity See this paper: http://pubs.acs.org/doi/pdf/10.1021/jp062734p Table 3 in particular.

Since we're using 100mM NaPO3, what shall I assume for the affinity in our guess?

Also, I looked up our stock, seems that we have naproxen as a powder. I looked up the solubility for our particular item: Soluble in DMSO, dimethyl formamide and 100% ethanol. Should we be worried? It does not mention water.. but it seems rather polar. (carboxylic acid group etc.)

This page suggests low solubility. http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+22204-53-1

bas-rustenburg commented 9 years ago

Whoops, meant to raise this issue in itctools...