choishingwan / PRSice

A software package for calculating, applying, evaluating and plotting the results of polygenic risk scores
http://prsice.info
GNU General Public License v3.0
185 stars 87 forks source link

[BUG] Execution Halted #274

Closed mdibiase1 closed 2 years ago

mdibiase1 commented 3 years ago

HI there,

Describe the bug My command is generating an 'Execution Halted' error

Error Log PRSice 2.3.3 (2020-08-05) https://github.com/choishingwan/PRSice (C) 2016-2020 Shing Wan (Sam) Choi and Paul F. O'Reilly GNU General Public License v3 If you use PRSice in any published work, please cite: Choi SW, O'Reilly PF. PRSice-2: Polygenic Risk Score Software for Biobank-Scale Data. GigaScience 8, no. 7 (July 1, 2019) 2021-08-04 20:11:02 PRSice_linux \ --a1 A1 \ --a2 A2 \ --bar-levels 0.001,0.05,0.1,0.2,0.3,0.4,0.5,1 \ --base CLOZUK_PGC2noclo.METAL.assoc.dosage.fix \ --binary-target T \ --bp BP \ --chr CHR \ --clump-kb 250kb \ --clump-p 1.000000 \ --clump-r2 0.100000 \ --extract PRS_CLOZUK_PGC2noclo.METAL.assoc.dosage.fix.valid \ --fastscore \ --model add \ --no-regress \ --nonfounders \ --num-auto 22 \ --out test \ --print-snp \ --pvalue P \ --score sum \ --seed 189902053 \ --snp SNP \ --stat BETA \ --target chr# \ --thread 1

Initializing Genotype file: chr# (bed)

Start processing CLOZUK_PGC2noclo.METAL.assoc.dosage ==================================================

SNP extraction/exclusion list contains 5 columns, will assume first column contains the SNP ID

Base file: CLOZUK_PGC2noclo.METAL.assoc.dosage.fix Header of file is: SNP CHR BP A1 A2 OR SE P DIRECTION

Reading 100.00% 8064799 variant(s) observed in base file, with: 1163532 variant(s) excluded based on user input 6901267 total variant(s) included from base file

Loading Genotype info from target ==================================================

486572 people (222640 male(s), 263776 female(s)) observed 486572 founder(s) included

Error: Execution halted

choishingwan commented 3 years ago

That's likely related to memory. i.e. It crashes because there isn't enough memory.

stale[bot] commented 2 years ago

This issue has been automatically marked as stale because it has not had recent activity. It will be closed if no further activity occurs. Thank you for your contributions.