Describe the bug
It seems like PRSice would calculate allele frequencies even if --maf is not there. Is that intended? If it is not necessary, then is there a way to turn it off?
Error Log
PRSice 2.3.5 (2021-09-20)
https://github.com/choishingwan/PRSice
(C) 2016-2020 Shing Wan (Sam) Choi and Paul F. O'Reilly
GNU General Public License v3
If you use PRSice in any published work, please cite:
Choi SW, O'Reilly PF.
PRSice-2: Polygenic Risk Score Software for Biobank-Scale Data.
GigaScience 8, no. 7 (July 1, 2019)
2021-12-01 08:17:57
./PRSice_linux \
--a1 A1 \
--a2 A2 \
--allow-inter \
--bar-levels 0.001,0.05,0.1,0.2,0.3,0.4,0.5,1 \
--base ... \
--binary-target T \
--bp BP \
--chr CHR \
--clump-kb 250kb \
--clump-p 1.000000 \
--clump-r2 0.100000 \
--extract ... \
--interval 5e-05 \
--keep ... \
--lower 5e-08 \
--num-auto 22 \
--out PRSice \
--pheno ... \
--pheno-col trait_prsice \
--pvalue P \
--seed 1822096333 \
--snp SNP \
--stat BETA \
--target-list target-list,ukb22828_c21_b0_v3.sample \
--thread 16 \
--type bgen \
--upper 0.5
Initializing Genotype info from file: target-list (bgen)
With external fam file: ukb22828_c21_b0_v3.sample
Start processing
...
==================================================
Only one column detected, will assume only SNP ID is
provided
Base file:
...
GZ file detected. Header of file is:
CHR BP A1 A2 SNP P OR
16543335 variant(s) observed in base file, with:
7463751 variant(s) excluded based on user input
1267696 ambiguous variant(s) excluded
7811888 total variant(s) included from base file
Loading Genotype info from target
==================================================
487409 people (222969 male(s), 264266 female(s)) observed
41291 founder(s) included
1152901 variant(s) not found in previous data
108257 variant(s) included
Calculate MAF and perform filtering on target SNPs
==================================================
108257 variant(s) included
...
To Reproduce
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Additional context
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Describe the bug It seems like PRSice would calculate allele frequencies even if --maf is not there. Is that intended? If it is not necessary, then is there a way to turn it off?
Error Log
To Reproduce If possible, provide a minimum working example for me to reproduce the problem. This can usually speed up the debugging process.
Additional context Add any other context about the problem here.